Work with Lee

Personalised nutrition and lifestyle programmes informed by evolutionary medicine. Both programmes are grounded in the Lipid Encephalisation and Mismatch Hypothesis (LEMH, 2026) and structured through P-U Medicine — a classification of clinical action distinguishing interventions that target the mechanisms of a problem from those that address its evolutionary origins.

LEMH and P-U Medicine are my own research frameworks, currently at preprint stage and pending peer review. I share them with clients as explanatory models. These are nutritional and educational services designed to complement, not replace, care from your GP or medical specialists. I do not diagnose or treat medical conditions.

Which programme is right for you?

Programme 1 — For people managing complex, long-standing health concerns who want to address the dietary, metabolic, and lifestyle drivers of how they feel and function. A comprehensive evolutionary-medicine investigation across all systems.

Programme 2 — For people with confirmed APOE genotype status (any allele) who want nutrition matched precisely to their metabolic architecture. A genotype-stratified precision-nutrition protocol.

Programme 1 Evolutionary Medicine Protocol
A comprehensive evolutionary-medicine investigation with the P-U Medicine framework

This programme applies the proximate–ultimate framework to identify the dietary, biological, and lifestyle factors relevant to your presentation, and builds a personalised, evidence-based nutrition and lifestyle protocol around your history, genetics, and goals. Interventions are organised by the causal depth at which they act: proximate nutrition and lifestyle support addressing mechanism, ultimate support addressing the evolutionary substrate.

Laboratory testing — all included

• DUTCH Complete — sex and stress hormone metabolites

• GI MAP + Zonulin — gut microbiome and pathogen testing

• Comprehensive blood test — thyroid, liver, kidney, immune function

• Genomics / SNP interpretation — DNA Core based on clinical presentation

Programme includes

• Clinical research — 6 hours dedicated case analysis including drug-nutrient and nutrient-nutrient interaction review

• P-U Medicine framework — proximate and ultimate nutritional and lifestyle interventions structured and distinguished throughout your protocol

• Full laboratory interpretation — evolutionary and functional correlations across all panels, used to inform nutritional and lifestyle recommendations

• Personalised protocols — evidence-based nutrition plan, nutraceutical protocol, and lifestyle recommendations

• Gastrointestinal support — functional medicine 5R nutritional plan where indicated

• Breathing and nervous system — Buteyko respiratory assessment and Polyvagal Theory coaching

• Maintenance protocol — provided on completion of the programme

• Direct messenger support — Monday to Friday throughout the programme via Practice Better

All laboratory testing included · Payment plans available · 6 × 60-minute consultations over 3 months · Online via Zoom · International clients welcomed · Fees discussed on enquiry

Best suited to people living with complex, long-standing health concerns who want to work on the evolutionary, genetic, and dietary drivers of their health through nutrition and lifestyle, alongside their existing medical care. Delivered as nutritional and lifestyle support; designed to complement, not replace, medical care.

Programme 2 LEMH Neurolithic Diet Protocol

APOE genotype-stratified precision nutrition

This programme delivers the full Neurolithic Diet protocol — an evolutionary dietary concept derived from LEMH, structured as a ketogenic, ancestral-fat nutritional pattern and matched to your APOE genotype. Where Programme 1 investigates across all systems, this one is built around a single question: what does your APOE genotype suggest for your nutrition, and how do we restore those ancestral dietary conditions? APOE genotyping and additional SNP testing provide the personalisation layer.

The Neurolithic Diet is offered as metabolic restoration — re-establishing dietary conditions closer to those under which human lipid metabolism evolved. It is a theoretical concept derived from my LEMH research, not a treatment for any named condition.

Littoral (APOE4), Boreal (APOE3), or Pelagic (APOE2) — each a distinct nutritional protocol built for that genotype's metabolic architecture, with precision personalisation above the genotype baseline.

Laboratory testing — all included

• GenoScan APOE + SNP panel — APOE, FADS1/2, PPARA, MTHFR, COMT

• Omega Index + DHA:AA ratio — neural phospholipid quality and DHA tissue saturation

• ApoB + LDL particle size — markers relevant to APOE4

• Blood BHB and GKI — ketogenic nutritional adaptation markers

• C15:0 / C17:0 — odd-chain fatty acid status and ancestral fat compliance marker

• Neural Zoomer Plus — neurological autoimmunity and blood-brain barrier integrity markers

• Lymphocyte Typing - analysis of immune cells

• Nail clipping stable isotope panel × 2 — objective dietary adherence verification, independent of self-reporting

• Comprehensive blood test — thyroid, liver, kidney, immune function

Programme includes

• Clinical research — 6 hours dedicated case analysis including full LEMH biomarker framework

• Neurolithic Diet assignment — Littoral (APOE4), Boreal (APOE3), or Pelagic (APOE2), with precision personalisation above genotype baseline

• Phase-by-phase implementation — three-phase nutritional protocol with progressive ketogenic dietary adaptation guidance

• Ancestral fat profile guidance — phospholipid-bound DHA loading, organ meat, bone marrow, and wild-type fat source nutritional protocol

• Ketogenic nutritional protocol — GKI and ApoB markers used to inform and personalise dietary recommendations throughout

• Nutraceutical protocol — evidence-based, including C15:0 supplementation where indicated

• Breathing and nervous system — Buteyko respiratory assessment and Polyvagal Theory coaching

• Maintenance protocol — provided on completion of the programme

• Direct messenger support — Monday to Friday throughout the programme via Practice Better

All laboratory testing included · Payment plans available · 6 × 60-minute consultations over 3 months · Online via Zoom · International clients welcomed · Fees discussed on enquiry.

Designed for people with confirmed APOE genotype status (any allele) who want a personalised, evolution-informed nutritional approach matched to their metabolic architecture, and who are committed to sustained dietary change. Delivered as nutritional and lifestyle support; designed to complement, not replace, medical care. Any decisions about your neurological or medical care should be made with your doctor.

Post-programme clinical support

On completion of either programme, clients receive a maintenance protocol to sustain the work begun. Ongoing nutritional support is available for clients who have completed a programme and wish to continue working together. Fee discussed on enquiry.

Questions before getting started? Get in touch. All consultations conducted online. International clients welcomed.

Beyond Functional Medicine Functional medicine asks what is dysregulated and works to correct it. This framework asks why the dysregulation exists at all — tracing it back to the evolutionary environment your genes were shaped by, and how far modern diet and lifestyle have drifted from it. Upstream and downstream is a metaphor, and one that assumes cause and effect share the same axis. They do not. Evolutionary causation is a different category of explanation. Translating that into clinical practice is ultimate medicine — a different category of intervention entirely. Functional medicine widens the proximate lens — it draws on diet, lifestyle, and nutritional biochemistry, looking further back along the causal chain than conventional medicine — but without the evolutionary context that explains why those variables matter, it remains proximate medicine. For APOE carriers especially, that distinction shapes how we think about the difference between managing a problem and addressing the conditions that give rise to it.

→ Learn more about LEMH and the Neurolithic Diet